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Article

Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses.

BMC cancer - 21 Nov 2014

Jiang Lin, Campagne Cécile, Sundström Elisabeth, Sousa Pedro, Imran Saima, Seltenhammer Monika, Pielberg Gerli, Olsson Mats J, Egidy Giorgia, Andersson Leif, Golovko Anna

Abstract excerpt

BACKGROUND: Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 (STX17), is associated with a very high incidence of cutaneous melanoma, but the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25413220
DOI: 10.1186/1471-2407-14-857
PMCID: PMC4254013

Genes

BRAF
GNA11
GNAQ
KIT
STX17
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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