Article
CADASIL and autoimmunity: coexistence in a family with the R169C mutation at exon 4 of the NOTCH3 gene.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2014
Paraskevas George P, Bougea Anastasia, Synetou Margarita, Vassilopoulou Sophia, Anagnostou Evangelos, Voumvourakis Konstantinos, Iliopoulos Alexios, Spengos Konstantinos
Abstract excerpt
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease caused by mutations of the NOTCH3 gene, which result in degeneration of vascular smooth muscle cells, arteriolar stenosis, and impaired cerebral blood flow. For clinicians this is the commonest hereditary adult-onset condition causing stroke and vascular dementia at...
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