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Article

A case of recurrent intracranial hemorrhage in CADASIL caused by NOTCH3 c.1759C>T heterozygous mutation.

Journal of clinical laboratory analysis - 1 Jan 2023

Chu Ying, Wang Qi, Ma Yue, Xu Linying, Ren Kexin, Liu Jiahui, Tao Dingbo, Cao Hua, Ji Xiaofei

Abstract excerpt

BACKGROUND: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebrovascular disease that is closely related to the NOTCH3 gene. Recurrent ischemic stroke, progressive cognitive dysfunction, and mental symptoms are the main clinical manifestations, whereas symptomatic intracranial hemorrhage is rare. METHODS: We detected a heterozygous mutation of c.1759C>T...

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Identifiers

PMID: 36604800
DOI: 10.1002/jcla.24840
PMCID: PMC9937875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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