Article
A novel Notch3 Gly89Cys mutation in a Serbian CADASIL family.
Acta neurologica Belgica - 1 Sept 2013
Pavlovic Aleksandra M, Dobricic V, Semnic R, Lackovic V, Novakovic I, Bajcetic M, Sternic N
Abstract excerpt
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable cause of stroke and vascular dementia in adults. We present a family from Serbia presenting with stroke and depression in the lack of vascular risk factors, with brain MRI indicating CADASIL. A novel NOTCH3 Gly89Cys mutation was located in exon 3. This report illustrates that in the...
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