A functional polymorphism C-509T in TGFβ-1 promoter contributes to susceptibility and prognosis of lone atrial fibrillation in Chinese population.

doi:10.1371/journal.pone.0112912

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Article

A functional polymorphism C-509T in TGFβ-1 promoter contributes to susceptibility and prognosis of lone atrial fibrillation in Chinese population.

PloS one - 1 Jan 2014

Cao Hailong, Zhou Qing, Lan Rongfang, Røe Oluf Dimitri, Chen Xin, Chen Yijiang, Wang Dongjin

Abstract excerpt

Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509 T polymorphism (rs1800469) was genotyped in a case-control study of 840 patients and 845 controls in Chinese population to explore the association between the polymorphism and susceptibility and prognosis of lone AF. As a result,...

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Identifiers

PMID: 25402477
DOI: 10.1371/journal.pone.0112912
PMCID: PMC4234495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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