IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation.

doi:10.1093/infdis/jiu636

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Article

IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation.

The Journal of infectious diseases - 15 May 2015

Wójtowicz Agnieszka, Gresnigt Mark S, Lecompte Thanh, Bibert Stephanie, Manuel Oriol, Joosten Leo A B, Rüeger Sina, Berger Christoph, Boggian Katia, Cusini Alexia, Garzoni Christian, Hirsch Hans H, Weisser Maja, Mueller Nicolas J, Meylan Pascal R, Steiger Jürg, Kutalik Zoltan, Pascual Manuel, van Delden Christian, van de Veerdonk Frank L, Bochud Pierre-Yves

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients. METHODS: Twenty-four SNPs from systematically selected genes were genotyped among 1101 SOT recipients (715 kidney transplant recipients, 190 liver transplant recipients, 102 lung transplant...

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PMID: 25398456
DOI: 10.1093/infdis/jiu636

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DEFB1

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