Article
Cross-reactivity of EGFR mutation-specific immunohistochemistry assay in HER2-positive tumors.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2015
Verdu Montse, Trias Isabel, Roman Ruth, Rodon Natalia, Pubill Carme, Arraiza Nuria, Martinez Begonya, Garcia-Pelaez Beatriz, Serrano Teresa, Puig Xavier
Abstract excerpt
The coexpression of HER2 and EGFR L858R in a solitary nodule removed from the lung, whose mutation was not confirmed by molecular techniques, made us think about the possible existence of a cross-reaction between HER2 and the EGFR L858R-specific antibody. Our study was designed to further analyze the existence of this cross-reaction and stress the need to exclude a metastatic breast cancer when dealing with EGFR...
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