Article
Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin.
The Journal of biological chemistry - 2 Jan 2015
Nguyen Ylan, Sugiman-Marangos Seiji, Harvey Hanjeong, Bell Stephanie D, Charlton Carmen L, Junop Murray S, Burrows Lori L
Abstract excerpt
Type IV pili (T4P) contain hundreds of major subunits, but minor subunits are also required for assembly and function. Here we show that Pseudomonas aeruginosa minor pilins prime pilus assembly and traffic the pilus-associated adhesin and anti-retraction protein, PilY1, to the cell surface. PilV, PilW, and PilX require PilY1 for inclusion in surface pili and vice versa, suggestive of complex formation. PilE...
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