Article
PilF is an outer membrane lipoprotein required for multimerization and localization of the Pseudomonas aeruginosa Type IV pilus secretin.
Journal of bacteriology - 1 Nov 2008
Koo Jason, Tammam Stephanie, Ku Shao-Yang, Sampaleanu Liliana M, Burrows Lori L, Howell P Lynne
Abstract excerpt
Type IV pili (T4P) are retractile appendages that contribute to the virulence of bacterial pathogens. PilF is a Pseudomonas aeruginosa lipoprotein that is essential for T4P biogenesis. Phenotypic characterization of a pilF mutant confirmed that T4P-mediated functions are abrogated: T4P were no longer present on the cell surface, twitching motility was abolished, and the mutant was resistant to infection by T4P...
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