Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes.

doi:10.1161/JAHA.114.001263

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Article

Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes.

Journal of the American Heart Association - 11 Nov 2014

Tanaka Atsushi, Yuasa Shinsuke, Mearini Giulia, Egashira Toru, Seki Tomohisa, Kodaira Masaki, Kusumoto Dai, Kuroda Yusuke, Okata Shinichiro, Suzuki Tomoyuki, Inohara Taku, Arimura Takuro, Makino Shinji, Kimura Kensuke, Kimura Akinori, Furukawa Tetsushi, Carrier Lucie, Node Koichi, Fukuda Keiichi

Abstract excerpt

BACKGROUND: Despite the accumulating genetic and molecular investigations into hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops and worsens pathologically and clinically in terms of the genetic-environmental interactions. Establishing a human disease model for HCM would help to elucidate these disease mechanisms; however, cardiomyocytes from patients are not easily obtained for...

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PMID: 25389285
DOI: 10.1161/JAHA.114.001263
PMCID: PMC4338713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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