Article
Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2005
Wolf Cordula M, Moskowitz Ivan P G, Arno Scott, Branco Dorothy M, Semsarian Christopher, Bernstein Scott A, Peterson Michael, Maida Michael, Morley Gregory E, Fishman Glenn, Berul Charles I, Seidman Christine E, Seidman J G
Abstract excerpt
Sarcomere protein gene mutations cause hypertrophic cardiomyopathy (HCM), a disease with distinctive histopathology and increased susceptibility to cardiac arrhythmias and risk for sudden death. Myocyte disarray (disorganized cell-cell contact) and cardiac fibrosis, the prototypic but protean features of HCM histopathology, are presumed triggers for ventricular arrhythmias that precipitate sudden death events. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.