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Gene Expression and Cytokine Profile Correlate With Mycobacterial Growth in a Human BCG Challenge Model

7 Nov 2014

Abstract excerpt

BACKGROUND: Bacillus Calmette-Guerin (BCG) vaccine is the most widely administered vaccine in the world, yet its mechanism of action remains unclear. We hypothesize that certain immune pathways are associated with reduced mycobacterial growth following BCG challenge in human volunteers. METHODS: We used samples from a mycobacterial challenge in which previously BCG-vaccinated or BCG-naive adults in the United...

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PMID: 25381367
DOI: 10.1093/infdis/jiu615

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