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Article

'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.

Human molecular genetics - 1 Mar 2015

Gazina Elena V, Leaw Bryan T W, Richards Kay L, Wimmer Verena C, Kim Tae H, Aumann Timothy D, Featherby Travis J, Churilov Leonid, Hammond Vicki E, Reid Christopher A, Petrou Steven

Abstract excerpt

Developmentally regulated alternative splicing produces 'neonatal' and 'adult' isoforms of four Na(+) channels in human brain, NaV1.1, NaV1.2, NaV1.3 and NaV1.6. Heterologously expressed 'neonatal' NaV1.2 channels are less excitable than 'adult' channels; however, functional importance of this difference is unknown. We hypothesized that the 'neonatal' NaV1.2 may reduce neuronal excitability and have a...

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PMID: 25378553
DOI: 10.1093/hmg/ddu562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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