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Article

Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy.

Brain : a journal of neurology - 1 May 2010

Liao Yunxiang, Deprez Liesbet, Maljevic Snezana, Pitsch Julika, Claes Lieve, Hristova Dimitrina, Jordanova Albena, Ala-Mello Sirpa, Bellan-Koch Astrid, Blazevic Dragica, Schubert Simone, Thomas Evan A, Petrou Steven, Becker Albert J, De Jonghe Peter, Lerche Holger

Abstract excerpt

Many idiopathic epilepsy syndromes have a characteristic age dependence, the underlying molecular mechanisms of which are largely unknown. Here we propose a mechanism that can explain that epileptic spells in benign familial neonatal-infantile seizures occur almost exclusively during the first days to months of life. Benign familial neonatal-infantile seizures are caused by mutations in the gene SCN2A encoding...

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Source

Identifiers

PMID: 20371507
DOI: 10.1093/brain/awq057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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