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Article

TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.

The Journal of biological chemistry - 19 Dec 2014

Wi Sae Mi, Moon Gyuyoung, Kim Juhong, Kim Seong-Tae, Shim Jae-Hyuck, Chun Eunyoung, Lee Ki-Young

Abstract excerpt

ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) is known as a multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGF-β, and BMP. Here, we report a new regulatory role of ECSIT in TLR4-mediated signal. By LPS stimulation, ECSIT formed a high molecular endogenous complex including TAK1 and TRAF6, in which ECSIT interacted with each protein and regulated...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25371197
DOI: 10.1074/jbc.M114.597187
PMCID: PMC4271209

Genes

ECSIT
TRAF6
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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