Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.

doi:10.1111/gtc.12198

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Article

Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2015

Jiang Li, Hara-Kuge Sayuri, Yamashita Shun-Ichi, Fujiki Yukio

Abstract excerpt

Pexophagy can be experimentally induced in mammalian cells by removing the culture serum. Pex14p, a peroxisomal membrane protein essential for matrix protein import in docking of soluble receptor Pex5p, is involved in the mammalian autophagic degradation of peroxisomes and interacts with the lipidated form of LC3, termed LC3-II, an essential factor for autophagosome formation, under the starvation condition in...

Topics

Animals
Autophagy
CHO Cells
Cricetulus
Membrane Proteins
Microtubule-Associated Proteins
Mutation
Peroxisomes
Protein Binding

Source

Open in PubMed

Identifiers

PMID: 25358256
DOI: 10.1111/gtc.12198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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