Article
Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese.
Journal of human genetics - 1 Jan 2015
Zhu Yunlong, Wang Zhongliang, Ni Jianliang, Zhang Yi, Chen Meijuan, Cai Jun, Li Xiao, Zhang Wen, Zhang Chen
Abstract excerpt
Abnormalities in mitochondrial complex I, which is responsible for controlling mitochondrial function, have been implicated in a variety of diseases associated with mitochondrial dysfunction, potentially including schizophrenia. The NADH dehydrogenase Fe-S protein 1 (NDUFS1) is the largest subunit of complex I. To explore whether the encoding NDUFS1 gene confers susceptibility to schizophrenia or is associated...
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