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Article

Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance

10 Apr 2012

Abstract excerpt

Anti-EGFR therapy is among the most promising molecular targeted therapies against cancer developed in the past decade. However, drug resistance eventually arises in most, if not all, treated patients. Emerging evidence has linked epigenetic changes, such as DNA methylation at CpG islands, to the development of resistance to multiple anticancer drugs. In addition, genes that are differentially methylated have...

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PMID: 22487682
DOI: 10.4161/cc.20120

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