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Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer

28 Oct 2014

Abstract excerpt

BACKGROUND: Genomic instability resulting in copy number variation is a hallmark of malignant transformation and may be identified through massive parallel sequencing. Tumor-specific cell free DNA (cfDNA) present in serum and plasma provides a real-time, easily accessible surrogate. METHODS: DNA was extracted from serum of 204 patients with prostate cancer (Gleason score 2-10), 207 male controls, and patients...

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PMID: 25348670
DOI: 10.1373/clinchem.2014.226571

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