Article
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4.
Nature immunology - 1 Dec 2014
Alsina Laia, Israelsson Elisabeth, Altman Matthew C, Dang Kristen K, Ghandil Pegah, Israel Laura, von Bernuth Horst, Baldwin Nicole, Qin Huanying, Jin Zongbo, Banchereau Romain, Anguiano Esperanza, Ionan Alexei, Abel Laurent, Puel Anne, Picard Capucine, Pascual Virginia, Casanova Jean Laurent, Chaussabel Damien
Abstract excerpt
Loss of function of the kinase IRAK4 or the adaptor MyD88 in humans interrupts a pathway critical for pathogen sensing and ignition of inflammation. However, patients with loss-of-function mutations in the genes encoding these factors are, unexpectedly, susceptible to only a limited range of pathogens. We employed a systems approach to investigate transcriptome responses following in vitro exposure of patients'...
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