Article
Inherited disorders of human Toll-like receptor signaling: immunological implications.
Immunological reviews - 1 Feb 2005
Ku Cheng-Lung, Yang Kun, Bustamante Jacinta, Puel Anne, von Bernuth Horst, Santos Orchidée Filipe, Lawrence Tatiana, Chang Huey-Hsuan, Al-Mousa Hamoud, Picard Capucine, Casanova Jean-Laurent
Abstract excerpt
In vitro nine of 10 known human Toll-like receptors (TLRs) are engaged by well-defined chemical agonists that mimic microbial compounds, raising the possibility that human TLRs play a critical role in protective immunity in vivo. We thus review here the recently described human primary immunodeficiencies caused by germline mutations in genes encoding molecules involved in cell signaling downstream from TLRs....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.