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Article

The role of microRNAs in cell fate determination of mesenchymal stem cells : balancing adipogenesis and osteogenesis

30 Jun 2015

Abstract excerpt

Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into adipocytes, osteoblasts, or chondrocytes. A mutually inhibitory relationship exists between osteogenic and adipogenic lineage commitment and differentiation. Such cell fate decision is regulated by several signaling pathways, including Wnt and bone morphogenetic protein (BMP). Accumulating evidence indicates that microRNAs...

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PMID: 25341923
DOI: 10.5483/bmbrep.2015.48.6.206

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