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The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment

9 Jun 2017

Abstract excerpt

Osteoblasts and adipocytes share a common mesenchymal progenitor in the bone marrow. This implies that a reciprocal relationship exists between osteogenic and adipogenic differentiation. Further, cells of osteoblast lineage transdifferentiate into adipocytes under some circumstances. Dysregulation of osteo-adipogenic fate-determination leads to bone diseases such as osteoporosis, accompanied by an increase in...

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PMID: 28598385
DOI: 10.3390/ijms18061236

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