Article
The great evolutionary divide: two genomic systems biologies of aging.
Interdisciplinary topics in gerontology - 1 Jan 2015
Rose Michael R, Cabral Larry G, Philips Mark A, Rutledge Grant A, Phung Kevin H, Mueller Laurence D, Greer Lee F
Abstract excerpt
There is not one systems biology of aging, but two. Though aging can evolve in either sexual or asexual species when there is asymmetric reproduction, the evolutionary genetics of aging in species with frequent sexual recombination are quite different from those arising when sex is rare or absent. When recombination is rare, selection is expected to act chiefly on rare large-effect mutations, which purge genetic...
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