Article
Gene expression profiling and subgroup identification of oligodendrogliomas.
Oncogene - 5 Aug 2004
Huang Hervé, Okamoto Yoshikazu, Yokoo Hideaki, Heppner Frank L, Vital Anne, Fevre-Montange Michelle, Jouvet Anne, Yonekawa Yasuhiro, Lazaridis Emmanuel N, Kleihues Paul, Ohgaki Hiroko
Abstract excerpt
The histological diagnosis of low-grade astrocytomas and oligodendrogliomas (WHO grade II) is often challenging, particularly in cases that show both astrocytic and oligodendroglial differentiation. We carried out gene expression profiling on 17 oligodendrogliomas (93% with LOH 1p and/or 19q) and 15 low-grade astrocytomas (71% with a TP53 mutation), using a cDNA array containing 1176 cancer-related genes. In...
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