Article
miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
PloS one - 1 Jan 2014
Shen Yuanming, Zhou Jiansong, Li Yang, Ye Feng, Wan Xiaoyun, Lu Weiguo, Xie Xing, Cheng Xiaodong
Abstract excerpt
Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers. Here, we showed the association of paclitaxel-resistance with miR-375 over-expression and epithelial-mesenchymal transition inducement in cervical cancer. Using different cervical cancer cell models, we found...
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