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Article

Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway.

Molecular cancer - 19 Oct 2014

Hou Chun-Han, Lin Feng-Ling, Hou Sheng-Mon, Liu Ju-Fang

Abstract excerpt

BACKGROUND: Osteosarcoma is the most common primary malignant tumor in children and young adults, and its treatment requires effective therapeutic approaches because of a high mortality rate for lung metastasis. Epithelial to mesenchymal transition (EMT) has received considerable attention as a conceptual paradigm for explaining the invasive and metastatic behavior during cancer progression. The cysteine-rich...

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Source

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Identifiers

PMID: 25326651
DOI: 10.1186/1476-4598-13-236
PMCID: PMC4210521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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