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Article

Remifentanil-induced cerebral blood flow effects in normal humans: dose and ApoE genotype.

Anesthesia and analgesia - 1 Jul 2007

Kofke W Andrew, Blissitt Patricia A, Rao Hengyi, Wang Jiongjiong, Addya Kathakali, Detre John

Abstract excerpt

BACKGROUND: Opioids have been linked to limbic system activation and, in animals, to neurotoxicity. Limbic system nonpharmacologic activation patterns have been linked to the Apolipoprotein E (ApoE) allelic distribution. We tested the hypothesis that, in the absence of surgery, small doses of remifentanil produce limbic system activation in humans which varies with dose and ApoE genotype. METHODS: Twenty-seven...

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Source

Identifiers

PMID: 17578972
DOI: 10.1213/01.ane.0000266490.64814.ff

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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