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Article

Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia.

Science translational medicine - 15 Oct 2014

Bochner David N, Sapp Richard W, Adelson Jaimie D, Zhang Siyu, Lee Hanmi, Djurisic Maja, Syken Josh, Dan Yang, Shatz Carla J

Abstract excerpt

During critical periods of development, the brain easily changes in response to environmental stimuli, but this neural plasticity declines by adulthood. By acutely disrupting paired immunoglobulin-like receptor B (PirB) function at specific ages, we show that PirB actively represses neural plasticity throughout life. We disrupted PirB function either by genetically introducing a conditional PirB allele into mice...

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Identifiers

PMID: 25320232
DOI: 10.1126/scitranslmed.3010157
PMCID: PMC4476552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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