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Conflicting consequences of immunity to cancer versus autoimmunity to neurons: Insights from paraneoplastic disease

16 Oct 2014

Abstract excerpt

Immunologists are well aware that cancer regression and increased patient survival with the use of checkpoint inhibitors, such as ipilimumab, an antibody directed against cytotoxic T-lymphocyte-associated antigen 4, CTLA-4 (CD152), is accompanied by concomitant autoimmunity. For over 30 years, a small group of investigators have shown that the rare paraneoplastic syndromes are caused by immunity to shared...

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PMID: 25319369
DOI: 10.1002/eji.201445191

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