Article
Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes.
European journal of neurology - 1 Dec 2007
de Beukelaar J W, Sillevis Smitt P A, Hop W C, Kraan J, Hooijkaas H, Verjans G M G M, Gratama J W
Abstract excerpt
In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies, neuron-specific Hu antigens expressed by the tumour hypothetically trigger an immune response that cross-reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized cell-mediated immune pathogenesis of these syndromes, we...
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