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Article

Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study.

Journal of gastroenterology and hepatology - 1 Apr 2015

Zaloumis Sophie G, Allen Katrina J, Bertalli Nadine A, Turkovic Lidija, Delatycki Martin B, Nicoll Amanda J, McLaren Christine E, English Dallas R, Hopper John L, Giles Graham G, Anderson Gregory J, Olynyk John K, Powell Lawrie W, Gurrin Lyle C

Abstract excerpt

BACKGROUND AND AIM: The risk of hemochromatosis-related morbidity for HFE simple heterozygosity for either the C282Y or H63D substitutions in the HFE protein was assessed using a prospective community-based cohort study. METHODS: HFE genotypes were measured for 31,192 persons of northern European descent, aged between 40 and 69 years when recruited to the Melbourne Collaborative Cohort Study, and subjects were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25311314
DOI: 10.1111/jgh.12804
PMCID: PMC4782752

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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