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Female Reproductive Decline Is Determined by Remaining Ovarian Reserve and Age

13 Oct 2014

Abstract excerpt

The early decline and loss of female fertility in humans and other species represents an evolutionary paradox. Despite being born with a vast stock of oocytes, females encounter an exhaustion of ovarian reserve and sterility half way through their natural lives. Female reproductive ageing has been proposed to proceed as an ongoing decline in ovarian reserve, determined by remaining ovarian follicle number....

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PMID: 25310678
DOI: 10.1371/journal.pone.0108343

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