Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer

Abstract excerpt

AIMS: Epigenetic changes are of crucial importance in cancer development and are potentially reversible; they are therefore targets of interest for anti-cancer therapy. The aim of this study was to investigate the clinical prognostic value of the histone deacetylases SIRT1, HDAC1 and HDAC2 and the histone modifications H4K16Ac and H3K56Ac in colorectal cancer. METHODS AND RESULTS: The epigenetic markers were...

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