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Article

Deregulated expression of HDAC3 in colorectal cancer and its clinical significance

31 Mar 2018

Abstract excerpt

BACKGROUND: To date, 4 classes of histone deacetylases (HDACs) have been identified in humans. Class I HDACs are zinc-dependent and NAD+-independent enzymes, and include 4 isoforms closely related to yeast RPD3: HDAC1, 2, 3, and 8. OBJECTIVES: The aims of the study were to quantitatively evaluate the expression of HDAC3 in colorectal cancer (CRC) and to correlate its expression levels with clinicopathological...

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PMID: 29558042
DOI: 10.17219/acem/66207

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