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Article

BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.

Cancer letters - 28 Jan 2015

Burdak-Rothkamm Susanne, Rothkamm Kai, McClelland Keeva, Al Rashid Shahnaz T, Prise Kevin M

Abstract excerpt

Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct DNA damage in the targeted cell and intercellular signalling leading to a broad range of bystander effects. This study aims to elucidate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25304378
DOI: 10.1016/j.canlet.2014.09.043
PMCID: PMC4259524

Genes

BRCA1
FANCD2
ATM
ATR
UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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