Article
BAF200 is required for heart morphogenesis and coronary artery development.
PloS one - 1 Jan 2014
He Lingjuan, Tian Xueying, Zhang Hui, Hu Tianyuan, Huang Xiuzhen, Zhang Libo, Wang Zhong, Zhou Bin
Abstract excerpt
ATP-dependent SWI/SNF chromatin remodeling complexes utilize ATP hydrolysis to non-covalently change nucleosome-DNA interactions and are essential in stem cell development, organogenesis, and tumorigenesis. Biochemical studies show that SWI/SNF in mammalian cells can be divided into two subcomplexes BAF and PBAF based on the subunit composition. ARID2 or BAF200 has been defined as an intrinsic subunit of PBAF...
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