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Article

Genome measures used for quality control are dependent on gene function and ancestry.

Bioinformatics (Oxford, England) - 1 Feb 2015

Wang Jing, Raskin Leon, Samuels David C, Shyr Yu, Guo Yan

Abstract excerpt

MOTIVATION: The transition/transversion (Ti/Tv) ratio and heterozygous/nonreference-homozygous (het/nonref-hom) ratio have been commonly computed in genetic studies as a quality control (QC) measurement. Additionally, these two ratios are helpful in our understanding of the patterns of DNA sequence evolution. RESULTS: To thoroughly understand these two genomic measures, we performed a study using 1000 Genomes...

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Share to Evolution, Molecular
Share to Genome, Human
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to High-Throughput Nucleotide Sequencing

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Share to Polymorphism, Single Nucleotide

Share to Quality Control

Source

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Identifiers

PMID: 25297068
DOI: 10.1093/bioinformatics/btu668
PMCID: PMC4308666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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