Article
A significant reduction in the frequency of HIV-1 drug resistance in Québec from 2001 to 2011 is associated with a decrease in the monitored viral load.
PloS one - 1 Jan 2014
Charest Hugues, Doualla-Bell Florence, Cantin Régis, Murphy Donald G, Lemieux Linda, Brenner Bluma, Hardy Isabelle, Moisi Daniela, Lo Ernest, Baril Jean-Guy, Wainberg Mark A, Roger Michel, Tremblay Cécile
Abstract excerpt
BACKGROUND: HIV drug resistance represents a major threat for effective treatment. We assessed the trends in the frequency of drug resistance mutations and the monitored viral load (VL) in treatment-naïve (TN) and treatment-experienced (TE) individuals infected with HIV-1 in Québec, Canada, between 2001 and 2011. METHODS AND FINDINGS: Resistance data were obtained from 4,105 and 5,086 genotypic tests performed on...
Topics
- Anti-HIV Agents
- Drug Resistance, Viral
- Epidemiological Monitoring
- HIV-1
- Humans
- Mutation
- Quebec
- Viral Load