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Article

The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p.

The EMBO journal - 3 Dec 2001

Galani K, Grosshans H, Deinert K, Hurt E C, Simos G

Abstract excerpt

In yeast, two aminoacyl-tRNA synthetases, MetRS and GluRS, are associated with Arc1p. We have studied the mechanism of this complex formation and found that the non-catalytic N-terminally appended domains of MetRS and GluRS are necessary and sufficient for binding to Arc1p. Similarly, it is the N-terminal domain of Arc1p that contains distinct but overlapping binding sites for MetRS and GluRS. Localization of...

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Identifiers

PMID: 11726524
DOI: 10.1093/emboj/20.23.6889
PMCID: PMC125769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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