Article
Advancing therapeutic discovery through phenotypic screening of the extracellular proteome using hydrodynamic intravascular injection.
Expert opinion on therapeutic targets - 1 Nov 2014
Baribault Helene, Majeti Jiangwen Z, Ge Hongfei, Wang Jinghong, Xiong Yumei, Gardner Jonitha, Yang Li, Gupte Jamila, Gong Yan, Pan Zheng, Cutler Gene, Kassner Paul, Tu Hua, Shan Bei, Wu Xinle, Li Yang
Abstract excerpt
OBJECTIVE: Although the human genome encodes ∼ 20,000 protein-coding genes, only a very small fraction of these have been explored as potential targets for therapeutic development. The challenge of identifying and validating new protein targets has contributed to the significant reduction in the productivity of the pharmaceutical industry in the recent decade, highlighting the continued need to find new...
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