Article
KATNB1 in the human testis and its genetic variants in fertile and oligoasthenoteratozoospermic infertile men.
Andrology - 1 Nov 2014
O'Donnell L, McLachlan R I, Merriner D Jo, O'Bryan M K, Jamsai D
Abstract excerpt
Oligoasthenoteratozoospermia (OAT) is a phenotype frequently observed in infertile men, and is defined by low spermatozoa number, abnormal spermatozoa morphology and poor motility. We previously showed that a mutation in the Katnb1 gene in mice causes infertility because of OAT. The KATNB1 gene encodes an accessory subunit of the katanin microtubule-severing enzyme complex; this accessory subunit is thought to...
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