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Article

Loss of Smarc proteins impairs cerebellar development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 2014

Moreno Natalia, Schmidt Christin, Ahlfeld Julia, Pöschl Julia, Dittmar Stefanie, Pfister Stefan M, Kool Marcel, Kerl Kornelius, Schüller Ulrich

Abstract excerpt

SMARCA4 (BRG1) and SMARCB1 (INI1) are tumor suppressor genes that are crucially involved in the formation of malignant rhabdoid tumors, such as atypical teratoid/rhabdoid tumor (AT/RT). AT/RTs typically affect infants and occur at various sites of the CNS with a particular frequency in the cerebellum. Here, granule neurons and their progenitors represent the most abundant cell type and are known to give rise to a...

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Source

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Identifiers

PMID: 25274825
DOI: 10.1523/JNEUROSCI.2560-14.2014
PMCID: PMC6608313

Genes

SMARCA4
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Smarc proteins impairs cerebellar development.PMID 25274825Read ↗

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