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Article

FSH-FSHR3-stem cells in ovary surface epithelium: basis for adult ovarian biology, failure, aging, and cancer.

Reproduction (Cambridge, England) - 1 Jan 2015

Bhartiya Deepa, Singh Jarnail

Abstract excerpt

Despite extensive research, genetic basis of premature ovarian failure (POF) and ovarian cancer still remains elusive. It is indeed paradoxical that scientists searched for mutations in FSH receptor (FSHR) expressed on granulosa cells, whereas more than 90% of cancers arise in ovary surface epithelium (OSE). Two distinct populations of stem cells including very small embryonic-like stem cells (VSELs) and ovarian...

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Topics

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Share to Aging
Share to Epithelium
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ovarian Neoplasms

Share to Primary Ovarian Insufficiency

Share to Receptors, FSH

Share to Stem Cells

Source

Identifiers

PMID: 25269615
DOI: 10.1530/REP-14-0220

Genes

BMP4
FSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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