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Article

Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of β-barrel proteins.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2014

Konovalova Anna, Perlman David H, Cowles Charles E, Silhavy Thomas J

Abstract excerpt

RcsF (regulator of capsule synthesis) is an outer membrane (OM) lipoprotein that functions to sense defects such as changes in LPS. However, LPS is found in the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how it monitors LPS. We show that RcsF has a transmembrane topology with the lipidated N terminus on the cell surface and the...

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Identifiers

PMID: 25267629
DOI: 10.1073/pnas.1417138111
PMCID: PMC4205638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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