Article
Genome-wide investigation of DNA methylation marks associated with FV Leiden mutation.
PloS one - 1 Jan 2014
Aïssi Dylan, Dennis Jessica, Ladouceur Martin, Truong Vinh, Zwingerman Nora, Rocanin-Arjo Ares, Germain Marine, Paton Tara A, Morange Pierre-Emmanuel, Gagnon France, Trégouët David-Alexandre
Abstract excerpt
In order to investigate whether DNA methylation marks could contribute to the incomplete penetrance of the FV Leiden mutation, a major genetic risk factor for venous thrombosis (VT), we measured genome-wide DNA methylation levels in peripheral blood samples of 98 VT patients carrying the mutation and 251 VT patients without the mutation using the dedicated Illumina HumanMethylation450 array. The genome-wide...
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