Article
Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats.
Psychopharmacology - 1 Mar 2015
Cippitelli Andrea, Ayanwuyi Lydia O, Barbier Estelle, Domi Esi, Lerma-Cabrera Jose M, Carvajal Francisca, Scuppa Giulia, Li Hongwu, Ubaldi Massimo, Heilig Markus, Roberto Marisa, Ciccocioppo Roberto
Abstract excerpt
INTRODUCTION: Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS: Here, we examined whether these point mutations account for the heightened anxiety-like behavior and stress...
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