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Article

Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation.

Pathology international - 1 Sept 2014

Ishii Jun, Sato Hanako, Yazawa Takuya, Shishido-Hara Yukiko, Hiramatsu Chie, Nakatani Yukio, Kamma Hiroshi

Abstract excerpt

One-third of lung malignancies demonstrate a proneural/neuroendocrine phenotype or type of differentiation. However, it has not been clearly elucidated how proneural/neuroendocrine differentiation is controlled in lung cancers. We recently demonstrated that the POU3F2 gene plays a significant role in proneural/neuroendocrine differentiation of lung cancers. Because class III POU genes (POU3F1, POU3F2, POU3F3, and...

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Source

Identifiers

PMID: 25243889
DOI: 10.1111/pin.12198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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