Insulinoma-associated Protein 1 (INSM1) Is a Better Marker for the Diagnosis and Prognosis Estimation of Small Cell Lung Carcinoma Than Neuroendocrine Phenotype Markers Such as Chromogranin A, Synaptophysin, and CD56.

doi:10.1097/PAS.0000000000001444

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Insulinoma-associated Protein 1 (INSM1) Is a Better Marker for the Diagnosis and Prognosis Estimation of Small Cell Lung Carcinoma Than Neuroendocrine Phenotype Markers Such as Chromogranin A, Synaptophysin, and CD56.

The American journal of surgical pathology - 1 Jun 2020

Sakakibara Rie, Kobayashi Maki, Takahashi Naoko, Inamura Kentaro, Ninomiya Hironori, Wakejima Ryo, Kitazono Satoru, Yanagitani Noriko, Horiike Atsushi, Ichinose Junji, Matsuura Yosuke, Nakao Masayuki, Mun Mingyon, Nishio Makoto, Okumura Sakae, Motoi Noriko, Ito Takaaki, Miyazaki Yasunari, Inase Naohiko, Ishikawa Yuichi

Abstract excerpt

To diagnose small cell lung carcinoma (SCLC), neuroendocrine (NE) phenotype markers such as chromogranin A, synaptophysin, and CD56 are helpful. However, because they are dispensable, SCLCs occur without apparent NE phenotypes. Insulinoma-associated protein 1 (INSM1) is a transcription factor for NE differentiation and has emerged as a single practical marker for SCLC. Using the surgical samples of 141 pulmonary...

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PMID: 32118626
DOI: 10.1097/PAS.0000000000001444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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