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Article

JC virus DNA is present in the mucosa of the human colon and in colorectal cancers

22 Jun 1999

Abstract excerpt

JC virus (JCV) is a polyoma virus that commonly infects humans. We have found T antigen DNA sequences of JCV in the mucosa of normal human colons, colorectal cancers, colorectal cancer xenografts raised in nude mice, and in the human colon cancer cell line SW480. A larger number of viral copies is present in cancer cells than in non-neoplastic colon cells, and sequence microheterogeneity occurs within individual...

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PMID: 10377441
DOI: 10.1073/pnas.96.13.7484

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